Interactions of Destruxin A with Silkworms’ Arginine tRNA Synthetase and Lamin-C Proteins
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چکیده
منابع مشابه
L-arginine recognition by yeast arginyl-tRNA synthetase.
The crystal structure of arginyl-tRNA synthetase (ArgRS) from Saccharomyces cerevisiae, a class I aminoacyl-tRNA synthetase (aaRS), with L-arginine bound to the active site has been solved at 2.75 A resolution and refined to a crystallographic R-factor of 19.7%. ArgRS is composed predominantly of alpha-helices and can be divided into five domains, including the class I-specific active site. The...
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15 صفحه اولMacromolecular interactions in protein synthesis: the interaction of tRNA with its biological partners (aminoacyl-tRNA synthetase,
The accessibility of phosphates towards ethylnitrosourea was studied in tRNA/aminoacyl-.tRNA synthetase complexes and in the ternary aminoacyltRNA/EF-Tu/GTP complex. When the tRNA is complexed to aminoacyl-tRNA synthetases, several phosphates are protected against the alkylation agent, the protection patterns varying according to the tRNA/aminoacyl-tRNA synthetase system. However in all cases p...
متن کاملThe C-terminal appended domain of human cytosolic leucyl-tRNA synthetase is indispensable in its interaction with arginyl-tRNA synthetase in the multi-tRNA synthetase complex.
Human cytosolic leucyl-tRNA synthetase is one component of a macromolecular aminoacyl-tRNA synthetase complex. This is unlike prokaryotic and lower eukaryotic LeuRSs that exist as free soluble enzymes. There is little known about it, since the purified enzyme has been unavailable. Herein, human cytosolic leucyl-tRNA synthetase was heterologously expressed in a baculovirus system and purified to...
متن کاملThe Enzymatic Paradox of Yeast Arginyl-tRNA Synthetase: Exclusive Arginine Transfer Controlled by a Flexible Mechanism of tRNA Recognition
Identity determinants are essential for the accurate recognition of transfer RNAs by aminoacyl-tRNA synthetases. To date, arginine determinants in the yeast Saccharomyces cerevisiae have been identified exclusively in vitro and only on a limited number of tRNA Arginine isoacceptors. In the current study, we favor a full cellular approach and expand the investigation of arginine determinants to ...
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ژورنال
عنوان ژورنال: Toxins
سال: 2020
ISSN: 2072-6651
DOI: 10.3390/toxins12020137